Introduction

NutriVIbots ORTHOTREX!

Hello, Hello, Everyone! Meet NutriVIbots ORTHOTREX!!! ORTHOTREX is formulated in powder with 4 active ingredients so that it is easily consumed by you. Not to mention, ORTHOTREX is a vegetarian-friendly supplement. Just dissolve 1 sachet in 100mL of water, and drink it! Now, allows Auntie to explain each of the active ingredients. 

AvocafoFlex (Germany)

AvocadoFlex is branded active ingredient from Germany, which contains an avocado-soybean unsaponifiable (ASU) fraction. It helps in reducing the speed of degeneration of the joints in osteoarthritis people by protecting the cartilage from degradation, though it takes a long time to completely stop the degeneration. 

Image credited to www.bioriginal.com
Why AvocadoFlex is good for arthritic people? Let Auntie explain it to you. You see, AcovadoFlex inhibits the activation of NF-kB through anticatabolic actions that prevent the degradation of cartilages. Not only it preventing cartilages from degradation, but AvocadoFlex also promotes the repairs of cartilages by stimulating the synthesis of collagen in an action called anabolic. Additionally, it enhances the production of cartilages through chondroprotective actions that protect the chondrocytes, a cell that produces cartilage matrix [1]. AvocadoFlex also had anti-synovitis effects. This effect prevents the degeneration of the synovial membrane, restores the synovial cavity and improves synovial water content and quality. Further, it also has anti-inflammatory effects which prevent the actions of many inflammatory mediators and pro-inflammatory components [2]. Finally, the analgesic effects relieve the pain and stiffness of the joints[2]. Great? Of course! Auntie will only recommend the best for you!

Now you are wondering, what is cartilage?

Oh! Cartilage is the cushion-like connective tissue in joints, between the bones. That was your high school answer.

It is not wrong, but what exactly is cartilage in arthritis? In arthritis, we are more about articular cartilage that allows bones to glide over each other with little friction. It is a form of tissue that is smooth and white in colour, that covers both ends of the bones to form joints. Injury or normal wear and tear can damage the articular cartilage.

Articular cartilage, particularly in arthritis, is composed of 2 things - 10% chondrocytes and 90% extracellular matrix (ECM) [4]. ECM contains many types of collagen, glycoproteins, proteoglycans, and hyaluronan, which all of these components are regulated by chondrocytes, as explained by Akkiraju, H., and Nohe, A (2015) [3]. The regulation here means that the chondrocytes responsible to synthesize the components of ECM. They also explained that if there are factors like pro-inflammatory components, that initiate inflammation, present in the ECM, the chondrocytes structure and function changes, causing the degeneration of ECM.

Now here is Fish Collagen Peptide (France) plays a role.

The fish collagen peptide, or hydrolyzed collagen, is to helps you confront your arthritic problem! The hydrolyzed collagen does not just reduce the symptoms of arthritis, but also increases the production of chondrocytes, thus increase the production of collagen type 2. As mention earlier, one of the ECM components is collagen. You see, there are several types of collagen, however, collage type 2 is the most abundant in cartilage (90-95% of total collagen in ECM) [3]. This is why one of ORTHOTREX's main actions is to repair collagen type 2.

Image credited to naturelcollagen.com

Image credited to www.momables.com
Fine Oat Powder (Sweden)

Oat is a popular diet for those with heart problems. But did you know oat has more than just its cardiovascular benefits? Surprisingly, oat also very rich with potent anti-oxidant effects due to avenanthramides, a phenolic compound that only found in oats[5-8]. 

The anti-oxidant and anti-inflammation of the oat are observed by the reduction in C-reactive protein level, an inflammation marker produced by our liver [4-8]. Since arthritis may also cause due to being overweight, oat served as a solution in reducing the weight by reducing oxidative stress, decreasing the level of pro-inflammatory cytokines, and regulating body gut flora [6].

Rosehip Extract (Germany)

For ladies, Rose Hip is considered a beauty product for its skin radiant properties. Well, it is not wrong as Rose Hip does have anti-oxidant effects, which promotes protective effects against oxidative stress. In addition, Rose Hips also has anti-inflammatory properties that act on the pro-inflammatory cytokines, thus reduce the C-reactive protein level and arthritic pain [9-11]. In addition, rosehip also rich in Vitamin C. The extra benefits of having Vitamin C is that it has a synergistic effect with collagen, hence enhance the biosynthesis of collagen type 2, and also able to suppress the degradation of collagen/cartilage through suppression of MMP-13 gene expression (responsible for the degradation of the extracellular matrix of cartilage) [4]. Not to mention, both previous and recent studies found that Rose Hip is well tolerated by the volunteered arthritic participants, with no serious side effects reported. [10-11].

Alright! That is all about ORTHOTREX. Interested in it? Buy it Online with Auntie's shops at Shopee and Lazada.

References:
  1. Christiansen, B.A., Bhatti, S., Goudarzi, R. and Emami, S. (2015). Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. Sage; 6(1): 30-44. DOI: 10.1177/1947603514554992.
  2. Salehi, B., Rescigno, A., Dettori, T., Calina, D., Docea, A.O., Singh, L., Cebeci, F., Ozcelik, B., Bhia, M., Cho, W.C. and Martins, N. (2020). Review: Avocado-Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited. Biomolecules; 10. DOI: 10.3390/niom10010130.
  3. Akkiraju, H. and Nohe, A. (2015). Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration. J Dev Biol.; 3(4): 177-192. doi: 10.3390/jdb3040177.
  4. Sato, Y., Mera., H., Takahashi, D., Majima, T., Iwasaki, N., Wakitani, S., and Takagi, M. (2017). Synergistic effect of ascorbic acid and collagen addition on the increase in type 2 collagen accumulation in cartilage-like MSC sheet. Cytotechnology; 69: 405-416. DOI: 10.1007/s10616-016-9924-3.
  5. Meydani, M. (2009). Potential health benefits of avenanthramides of oats. Nutrion Reviews; 67(12): 731-735. https://doi.org/10.1111/j.1753-4887.2009.00256.x
  6. Zhang, Y., Ni, T., Zhang. D., Liu, H., Wang, J., and Sun, B. (2020). Consumption of avenanthramides extracted from oats reduces weight gain, oxidative stress, inflammation and regulates intestinal microflora in high fat diet-induced mice. Journal of Functional Foods; 65. https://doi.org/10.1016/j.jff.2019.103774
  7. Maliarova, M., Maliar, T., Kroslak, E., Sokol, J., Nemecel, P., amd Nechvatal, P. (2015). Antioxidant and proteinase inhibition activity of main oat avenanthramides. Journal of Food and Nutrion Research; 54(4): 346-353. 
  8. Tripathi, V., Singh, A., and Ashraf., M. T. (2018). Avenanthramides of Oats: Medicinal Importance and  Future Perspectives.  Pharmacognosy Reviews; 12(23).
  9. Warholm, O., Skaar, S., Hedman, E., Molmen, H. M. and Eik, L. (2003). The Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Current Therapeutic Research; 64(1). Doi: 10.1016/sSoo11-393X(03)00004-3.
  10. Winther, K. (2008). A standardized powder made from rosehips (Rosa canina L.) improves functions and reduces pain and the consumption of rescue medication in osteoarthritis. Osteoarthritis and Cartilage;16(1): S8-S9.
  11. Gruewald, J., Uebelhack, R., and More, M.I., (2019). Rosa canina - Rosehip pharmacological ingredients and molecular mechanics countering osteoarthritis - A systematic review. Phytomedicine; 60. https://doi.org/10.1016/j.phymed.2019.152958.

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